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The hunt for the Higgs boson witnessed what you would call an arms race between Chicago (Fermilab) and Geneva (CERN), that lasted for generations. Larger, bigger, crazier machines were built, reaching energies that were seen only once before in the whole history of the Universe: at the very moment of the Big Bang, and never again.
But the Higgs boson was nowhere to be found. This particle was so elusive that the Nobel Laureate and Higgs hunter Leon Lederman wrote a book to tell the story of this continuing failure. The original title for the book was That goddamn particle since there was no way to get your hand on it… But the editor decided to change it at the last moment into The God particle, without consulting with the author. Still, not even the Pope could figure this out.